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In the LEAD-5 trial, liraglutide (1.8 mg once daily) reduced HbA1c more than insulin glargine during the treatment period (26 weeks) [31]

They have no obvious drug release mechanism, and the ADC prepared by this strategy relies on the complete lysosomal proteolytic degradation of the antibody that releases the antibody-drug after internalization

It mostly comes from small, early studies and personal stories

More severe side effects are possible, including but not limited to a high fever, blistering at the injection site, and allergic symptoms such as itching, rash, hives, and vomiting

Theyre signaling molecules