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This approach is not part of the FDA-approved protocol, but it has a logical pharmacological basis and is gaining traction in clinical practice

Elevated IgE levels can indicate the presence of allergies, which may be associated with increased histamine release

CMS prefers the specific X-modifiers over the broad 59

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Research on human mast cells has shown that butyrate suppresses mast cell activation, reducing the release of histamine and related inflammatory mediators