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Remove the patch from the liner and press it firmly onto your skin

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Slowing your dose progression is different from splitting dosesit means staying at your current dose level for an extra week or two before moving to the next amount

Prior work has shown that depletion of KG, for instance via mutations in IDH1/2 that instead produce the oncometabolite D2-HG, inhibits KGDD activity leading to changes in DNA and histone methylation (Inoue et al., 2016

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