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In cultured astrocytes, TDP-43 elevates IL-1, IL-6, and TNF- levels, mirroring ALS patient blood profiles and stimulating microglial proliferation via NF-B activation [250, 251]
They have also been shown to decrease stress-related cortisol and amylase levels [90]
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This must be a different drug through the same IV access
Thus, whether a feedback mechanism exists between AMPK and glycolysis warrants further investigation
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