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Unlike normal astrocytes, which suppress cholesterol production under conditions such as high cell density, GBM cells frequently have sustained activation of the cholesterol biosynthetic pathway (69)

Consistent with this, 15 min after intraperitoneal (i.p.) administration of glucose, DIO mice treated with GLP-1RA/tesaglitazar showed equal insulin secretion relative to mice treated with the pharmacokinetically matched GLP-1RA control (Fig

9th Advances in CRC: Controversies and Emerging Approaches Symposium