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a , HT-1080 transfected with pBP GFP-cGPX4 WT , pBP GFP-cGPX4 R152H , pBabepuro (pBP) empty vector, pBP GFP-cGPX4 K48A , pBP GFP-cGPX4 K48L and pBP GFP-cGPX4 K125R-K127R were selected with puromycin and imaged with microscope
This gradual approach helps minimize potential side effects, particularly gastrointestinal symptoms
Moreover, Gao et al
Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels
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