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These drugs have a longer duration of action and are widely used for weight loss and diabetes management
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Cost is an additional barrier
Third, systematic replacement of flexible ether linkages and metabolically vulnerable substituents with bicyclic and conformationally constrained motifs produced substantial improvements in physicochemical and ADME parameters, including increased solubility, enhanced microsomal stability, reduced CYP inhibition, and lower P-gp liability, while maintaining sub-nanomolar to picomolar potency (Layton et al., 2023)
Glutathione is an important antioxidant that protects the liver against oxidative injury
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