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A leptin missense mutation associated with hypogonadism and morbid obesity

10.1210/10.1210/er.2006-0038 126 WangX.ZhouJ.DoyleM

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Elimination : Only 3-22% is excreted unchanged in the urine (~30% of clearance occurs in the kidneys)

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Sirt2 -KO mice hearts exhibit hyperactivated mTOR kinase activity Previous reports suggest that Sirt2 -KO mice develop cardiac hypertrophy in an age-dependent manner, and Sirt2 -KO mice are more sensitive to neurohormonal-induced cardiac hypertrophy (Sarikhani et al, 2018a