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It was proposed that disulfide formation alters catalytic efficiency by affecting the dynamic movements of the N-terminal loop (Figure 2 and Supplementary Table 3)

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Essentially, the toxin was less effective and the effects wore off quicker in Botox patients on GLP-1 weight loss medications

Study findings The study cohort consisted of 36,082 and 234,028 GLP-1 receptor agonist and DPP-4 inhibitor users, respectively, who were followed for a median of 1.3 and 1.7 years

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