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These drugs can induce apoptosis and disrupt cellular homeostasis, leading to irreversible SHL

This condition, mainly caused by bacterial infections, oxidative stress, alcohol or chronic allergen exposure, and dysbiosis, leads to the development of several pathologic conditions, including obesity, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver cirrhosis, neurodegeneration, cardiovascular diseases, inflammatory bowel disease, celiac disease, irritable bowel syndrome, type 1 diabetes mellitus (T1D), and several autoimmune conditions (Fig

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doi: 10.1016/j.bbrc.2019.06.015 96 WeiC