The phase III trials of liraglutide, semaglutide, and tirzepatide all showed improvements in self-reported physical functioning [14, 43, 44]
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[27] on the antidiabetogenic effect of intestinal factors, and in 1929 by Zung & La Barre [28] on the release of a substance from intestinal mucosa with properties to decrease glycaemia, signalled the start of the development of the incretin concept and the study of the relationships between the gut and the endocrine pancreas
These drugs reduce systolic blood pressure by about 2 to 6 points on average
The two compounds are chemically unrelated
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