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Discontinuation due to side effects was 7% (Wilding et al., NEJM 2021)
One 2023 study gave glutathione supplements to dogs with poor liver health
While that gap is meaningful, it was not dramatic enough for AOD-9604 to win approval as a standalone obesity drug, and formal development was paused in 2007
A clinical trial in 2015 linked an undisclosed GLP-1 to significant improvements in OSA severity, while a 2016 clinical trial found that weight loss resulting from liraglutide was significantly associated with a reduction in the apnea-hypopnea index (AHI)
Jensen T, et al
Oxidative Stress: As glutathione decreases, oxidative stress increases dramatically
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