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Writing to investors on Thursday, analysts at William Blair called this outcome underwhelming. Without demonstrating significant fibrosis improvement, they added, what makes pemvidutide different from other similar assets is unclear. While the Phase IIb IMPACT study met the MASH [metabolic dysfunction-associated steatohepatitis] resolution endpoint, we believe investors are considerably more interested in the other primary endpoint of fibrosis improvement, which correlates with liver failure, death and progression to cirrhosis or hepatocellular carcinoma, according to the analysts
doi: 10.1016/j.immuni.2022.12.003 71 MaJZhangHChenYLiuXTianJShenW
Begin with your previous maintenance dose rather than restarting at a lower dose, since your body has had time to reset its tolerance
Rapid weight loss , a desired therapeutic effect of GLP-1 therapy, may theoretically contribute
Always consult your healthcare provider before making any significant changes to your lifestyle
It is often used to manage nausea and vomiting during pregnancy under medical supervision
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