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The most commonly reported side effects were gastrointestinal symptoms such as nausea, vomiting and diarrhea
They reduce food cravings and lead to weight loss
Many people regain weight after stopping abruptly, which is why a planned maintenance strategy gradual dose review, protein and strength-training habits established during therapy, and continued follow-up matters more than the medicine itself
When you first lose weight: * you're carrying less body mass * your body needs fewer calories * you burn less energy moving around * your appetite often starts to creep back slightly So the calorie deficit that caused weight loss initially becomes smaller over time
however, this represents early-phase evidence only, and the mechanistic effects observed in trials including increased energy expenditure and lipolysis via glucagon receptor agonism have not yet been fully characterised in long-term human studies
The drug is expected to be available to the public early next year
