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Cardiovasc Res 69 : 562573 Jones GC and Riley GP (2005) ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis

In preclinical studies, metformin activates AMPK via inhibition of mitochondrial complex I, enhancing mitochondrial biogenesis and mitophagy [148], while pioglitazone promotes fatty acid oxidation, energy production, and reduces neuroinflammation [149]

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