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In rat pinealocytes (the melatonin-producing cells of the pineal gland), Epitalon was shown to upregulate both AANAT (arylalkylamine N-acetyltransferase, the rate-limiting enzyme in melatonin production) and pCREB (a transcription factor involved in melatonin gene expression)

doi: 10.1016/j.ygyno.2014.02.038 7 KannoYChenC-YLeeH-LChiouJ-FChenY-J

These findings open perspectives for biological tooth repair as an alternative to conventional filling materials

In rat models of inflammatory bowel disease, the peptide reduced inflammation, promoted mucosal healing, and improved intestinal barrier function

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