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Fat mass decreased by 17.0 kg with the combination, compared to 3.4 kg with the placebo, whereas lean mass decreased by 8.4 kg, compared to 2.6 kg

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Phase (approx.) Cagrilintide dose Frequency Weeks 14 0.25 mg Once weekly Weeks 58 0.5 mg Once weekly Weeks 912 1.0 mg Once weekly Weeks 1316 1.7 mg Once weekly Week 17 onward 2.4 mg (max studied) Once weekly This step-wise schedule mirrors the titration used in cagrilintide and CagriSema studies ( Lau et al., Lancet 2021

These protocols should complement rather than replace appropriate medical evaluation and physical therapy