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IGF-1 Des binds the IGF-1 receptor (IGF-1R) to induce intracellular signaling cascades through predominantly PI3K/Akt and MAPK/ERK pathway which control cellular proliferation, differentiation, survival signaling, and metabolic substrate utilization

Thats what researchers saw in rat wound models using peptide-incorporated collagen (PIC) dressings with GHK (PMC6073405)

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Different kinds of pH-cleavable nanocarriers utilizing pH difference between healthy and diseases cell have been reported for the target specific release of active pharmaceutical molecules

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