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Cited 2/3/16 Hansotia T, Drucker DJ (2005): Therapeutic Potential of the DPP-4 Inhibitors
In one study, a single dose led to a 2- to 10-fold increase in GH levels that lasted for nearly a week
M2-polarized TAMs collaborate with angiogenic factors, including epidermal growth factor (EGF) and placental-derived growth factor, within the TME
Split dosing can reduce side effects, provide more consistent appetite suppression throughout the week, and theoretically reduce peak receptor stimulation that drives desensitization
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