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GLP-1 therapies have demonstrated substantial weight-reduction benefits, with studies showing an average weight loss of 4.6 kg, a BMI reduction of 2.1 kg/m, and a decrease in waist circumference of 4.6 cm compared to placebo
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Individual responses vary significantly based on factors such as age, overall health, the rate of dose increases, and genetic differences in how the body processes medication
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N Engl J Med 373(1): 1122