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The relationship between AKI and CKD in patients with type 2 diabetes: an observational cohort study
PubMed Central , Clinical Toxicology (Philadelphia, Pa.) , vol
152 : 792794 Stoll AL, Severus WE, Freeman MP, Rueter S, Zboyan HA, Diamond E et al
Individual responses vary widely based on metabolism, insulin resistance, body composition and hormone sensitivity
Tirzepatide-Specific Safety Considerations GI symptoms are generally mild to moderate Risk of hypoglycemia when used with insulin or sulfonylureas Rare risk of pancreatitis (class effect) Possible thyroid C-cell effects (class warning) Heart rate increases have been documented, but are generally modest Retatrutide-Specific Safety Considerations Higher overall rate of side effects compared to tirzepatide in Phase 2 data More pronounced heart rate increase this is a dose-dependent effect directly related to glucagon receptor activation (glucagon is known to increase heart rate in pharmacological doses) At 12 mg doses, some participants experienced increases in heart rate of 46 bpm above baseline
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