surmount-1 tirzepatide obesity nejm 2022 weight loss percent Presented at #ECO2025: In the SURMOUNT-5 phase 3b trial involving adults with without type 2 diabetes, was superior to semaglutide in reducing body and waist circumference. Full trial results GLP-1 Medications for Weight Loss:

Drug choice, dose changes, and side-effect management should be decided with your doctor or licensed clinician

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Beyond 2.4 mg weekly, dose escalation is not standard clinical practice for GLP-1 weight loss therapy