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Summary: Long-term calorie restriction doesnt appear to directly impact IGF-1 levels in humans, although it may make it less active

doi: 10.1186/s12943-020-01238-x

This offers several advantages compared to purchasing separate vials and manual mixing: Unique reconstruction: a single injection of bacteriostatic water instead of 2, 3 or 4 separate reconstitutions Constant ratio: The ratio between peptides is optimized and identical from one bottle to another

Importantly, this relationship is relevant to humans as individuals with exceptional longevity are enriched with functional IGF-1R mutations 13 , while low IGF-1 levels predict better survival in female nonagenarians 16

In endurance exercise of low and moderate intensity, where fat is the dominant fuel, the patency of this transport has a real impact on the energy economy of muscle work