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The pathogenesis of NASH is complex and multifactorial, obesity and type 2 diabetes mellitus (T2DM) have been implicated as major risk factors

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The initial numbers from those trials suggest that the combination medication may be more effective than either semaglutide or cagrilinitide alone

Current evidence suggests the changes are more likely due to rapid weight loss, hormonal shifts, microbiome disruption, and dehydration rather than a direct drug effect