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In terms of the trial rationale, studies with GLP-1 receptor agonists have shown very consistently a dose-response effect on body weight loss with higher dosages, and once-daily formulations of semaglutide 7 mg and 14 mg have been approved for the treatment of type 2 diabetes and does provide clinically relevant weight loss, said Julio Rosenstock, MD, Director of Velocity Clinical Research at Medical City Dallas and Clinical Professor of Medicine at the University of Texas (UT) Southwestern

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Downregulation of SLC7A11 disrupts cysteine metabolism, leading to decreased intracellular cystine and GSH levels, impairing GPX4 activity and triggering lipid peroxide accumulation and ferroptosis (79,81,82)