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1987 Jan-Feb;8(1):45-8

Bevacizumab + chemotherapy versus chemotherapy alone in elderly patients with untreated metastatic colorectal cancer: a randomized phase II trial-PRODIGE 20 study results

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17 These adverse effects can be attributed to either direct gastrointestinal and bone marrow toxicity, mediated by folate antagonism, with symptoms such as nausea, vomiting, abdominal discomfort, oral mucositis and myelosuppression, or due to idiosyncratic or allergic reactions like pneumonitis

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miRNA is a novel gene regulator, and since miR-451 is amplified in HT patients and may lead to hypothyroidism, it is a highly significant molecule in the pathogenesis of HT