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Concomitant deficiencies (iron, folate), chronic illness, or drug interactions may blunt clinical response and warrant further evaluation
Any clinical research initiatives must be conducted under the guidance of the relevant Institutional Review Board (IRB)
Because the vitamin deposits into muscle rather than entering the vasculature immediately, intramuscular delivery produces a sustained release effect
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Results vary by patient
Many users find once-daily dosing more sustainable over multi-week protocols
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