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Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program

The associated shift in the cellular redox state may cause the activation of Nrf2, leading to this additional positive effect on metabolism of high doses of thiamine disulfides, compared to thiamine

However, some individuals prefer taking it with food if they experience mild stomach discomfort

Such a relationship is not surprising because most diurnal or nocturnal organisms display daily oscillations in energy intake, locomotor activity, and exposure to exogenous and internally generated oxidants (73)

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