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Largely because combining compounds with overlapping healing or anti-inflammatory reputations makes an appealing marketing story built on assumed synergy

Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: A pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme

Available data indicate that SGLT2-i cause plasma renin activity (PRA) increase in the early phase of treatment, while PRA and aldosterone levels remain unchanged in chronic treated patients

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Acta Endocrinol

Cagrilintide, on the other hand, was more balanced in how it activated both sensors