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Cytoplasmic staining for ABCA1 or GLP-1 was considered positive
Richard, MD
Karyomegaly and anisokaryosis are normal incidental findings, especially in older mice (Percy and Barthold 2001)
It expands the Context of Use of in vivo studies from "does the animal lose weight?" to "how does feeding behaviour change over 24-hour cycles, when does activity compensation occur, and what is the temporal relationship between metabolic and behavioural endpoints?" The Adverse Outcome Pathway Framework: Connecting the Dots The Adverse Outcome Pathway (AOP) framework offers a structured way to think about Context of Use across model types
Park, T
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