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Unlike stealth liposomes, which rely on the enhanced permeability and retention (EPR) effect for passive accumulation in diseased tissues, active targeting liposomes are functionalized with ligands that bind selectively to overexpressed receptors on target cells

This limitation is particularly evident in understanding the roles of GRX, GSNO, S-glutatylation, and S-nitrosylation processes

Semin Arthritis Rheum 30:8799 Murphy R, McConell G, Cameron-Smith D et al (2001) Creatine transporter protein content, localization, and gene expression in rat skeletal muscle

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It also decreases hepatic gluconeogenesis and glucose accumulation through modulation of AMPK

Interestingly, many researchers report increased energy levels after the initial adaptation period