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Diarrhea: Some people experience loose stools, especially after increasing their dose
Notably, neonatal hypoglycemia significantly increases the risk of epilepsy in later childhood (89)
The lower risk of the primary end point in LEADER was primarily driven by a significantly lower rate of cardiovascular death
However, the signal transduction pathway, whereby changes in intracellular ATP alter the activity of GI neurons, is completely different
Dosing is flexible, allowing for extension of dose-escalation intervals, dose reduction, and treatment pauses
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