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Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
Key safety caveat MK-677 increases appetite substantially (its mechanism overlaps with ghrelin, the hunger hormone), causes water retention, and raises fasting glucose in multiple trials
10.1038/mp.2016.19 274 SuriS.ChiesaS
Cytosol was fractionated from mitochondria by differential centrifugation 34
Cardiovascular outcomes trials and meta-analyses consistently demonstrate reductions in MACE, with particularly robust effects on stroke [5, 12, 13]
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