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2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Supplementary Table S1

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Senescent cells amplify the local inflammatory microenvironment by secreting senescence-associated secretory phenotype (SASP) factors ( Quantitative analyses using high-resolution computed tomography (HRCT) confirm that IL-17A levels in severe COPD patients positively correlate with small airway disease and wall thickening (90)

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