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Changes to eyesight Sudden changes to your eyesight If you notice a sudden loss of vision or rapidly worsening eyesight during treatment with semaglutide, urgently contact your doctor

In the head-to-head SURMOUNT-5 trial (NEJM 2025), tirzepatide produced 20.2% weight loss vs 13.7% for semaglutide at 72 weeks

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