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E.ByrnesW
When HSL is in the nucleus, the levels of PGC-1 mRNA, as well as the pre-mRNA, are reduced
Therefore, the following mechanisms can explain this
Moreover, mitochondrial DAMPs released from stressed cells-such as mtDNA and cardiolipin-serve as potent activators of pattern recognition receptors (e.g., TLR9, cGAS-STING, and NLRP3), perpetuating inflammation (Mills et al., 2017)
The Holy Grail of Curcumin and its Efficacy in Various Diseases: Is Bioavailability Truly a Big Concern
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