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Moreover, most of the clinical trials fail to enter the market with novel effective drugs, with just 1 out of 100 new molecules developed against AD that reaches the pharmaceutical market (Nichols et al., 2019
Preclinical evidence shows spinal GLP-1R activation attenuates bone cancer-induced allodynia via -endorphin release [24]
Blood 134, 14871497
This idea, called the Carbohydrate-Insulin Model (CIM), is detailed in a paper by Ludwig et al (2021)
Mol Aspects Med, 25(5-6), 455-73
Thang ND, Diep PN, Lien PT, Lien LT
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