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Despite the promising individual effects of SGLT2is and GLP-1RAs on MASLD 12,13,14,15,16 , there remains a significant research gap in understanding the potential benefits of combination therapy
The standard protocol already accounts for this by starting at 2.5 mg and increasing every four weeks, but for some people, even 2.5 mg hits too hard
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One of naltrexones advantages is that you dont have to stop drinking before starting it
There's a reason why that's not happening
Hitting the protein target is harder on retatrutide under -eating protein exactly when the body needs it most
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