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Metformin, conversely, interferes with the calcium-dependent absorption of the B12-Intrinsic Factor complex in the terminal ileum (the end of the small intestine)
However, for most people with normal B12 levels, supplementation or injections do not significantly affect metabolism or fat loss
They are often recommended for individuals who struggle to absorb B12 from food or supplements, such as those with certain medical conditions or dietary restrictions
This guide explains access rules using simple language and practical explanations
Scientific References Obesity update guideline draft
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