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Extended Data Figure 8 Effects of the PAM binding pocket mutations on potency of compound 2
Lee Sandler If you struggle with needle anxiety or want a budget-friendly entry point, oral GLP-1 pills are worth it
It feels like the next phase of GLP-1s may shift from pure efficacy to quality of weight loss (fat vs lean mass) and long-term metabolic outcomes
Constipation is a top-3 cause of GLP-1 discontinuation and it is almost always preventable with hydration and gradual fibre introduction
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