AOD9604 alone significantly improved both gross morphological and histopathological cartilage scores versus saline controls, and the combination of AOD9604 with hyaluronic acid produced superior outcomes to either agent administered alone including significantly shorter lameness periods
Answer: Because Dihexa is investigational, its long-term safety profile in humans is not fully established
In addition, premature drug release due to drug-lipid bilayer interactions compromises drug entrapment and limits the control of drug delivery [24, 25]
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