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Physiologically based pharmacokinetic (PBPK) models aim to describe the absorption, distribution, metabolism, and elimination of a drug in a physiologically relevant compartmental structure, where each compartment represents an organ or a tissue
These assessments can identify any emerging concerns before they become problematic
The consistency of the safety profile across short-term and long-term trials suggests that AOD-9604 does not produce cumulative toxicity or delayed adverse effects that emerge only with chronic administration
3 In vitro characterization and calibration of TraQ-G
95% CI, 1.37 to 0.13
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