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Gibbons C, Caudwell P, Finlayson G, Webb DL, Hellstrom PM, Naslund E et al

Latent portasystemic encephalopathy

This triggers several mechanisms: enhanced insulin secretion in response to food, suppression of glucagon (which raises blood sugar), delayed gastric emptying, and reduced appetite signals

Most people start at 0.25 milligrams per week and move up, with the highest dose being 2.4 milligrams

For most patients this is the realistic upper limit of safe drinking on a cycle