how does tirzepatide work differently than semaglutide Unveiling the Therapeutic Potential of the Second-Generation Incretin Analogs and in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults Semaglutide vs. Tirzepatide for Obesity

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GLP-1 receptor agonists work by meticulously mimicking the natural incretin hormones your gut produces after eating

Novo Nordisk's challenge is that it is now in catch-up mode on efficacy

GLP-1 also works on hunger centers in the brain to prevent cravings

[PubMed] [PMC] Roy A, Sharma S, Nag TC, Katyal J, Gupta YK, Jain S (2022) Cognitive dysfunction and anxiety resulting from synaptic downscaling, hippocampal atrophy, and ventricular enlargement with intracerebroventricular streptozotocin injection in male Wistar rats

Retatrutide versus tirzepatide timing Tirzepatide is a dual GLP-1/GIP agonist with a half-life of about five days, shorter than retatrutide