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However, the exposure levels of this parenteral formulation are higher than those used in the evoke/evoke+ trials, and weight loss is more common in patients with severe dementia than in those included in evoke/evoke+ [65]

The TRIUMPH program includes evaluation of a 4mg maintenance dose alongside the 9mg and 12mg therapeutic doses, which could provide data to support this approach for Retatrutide specifically

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10.1111/ppe.12660 51 Quiarato LozanoA

The Takeaway Both semaglutide and tirzepatide are powerful tools, but they arent interchangeable

Multiple clinical trials have shown it reduces fasting blood glucose and produces modest weight loss, particularly in people with insulin resistance or type 2 diabetes