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We previously demonstrated that misfolded human -synuclein directly activates microglia via the classical pathway with increased expression of a subset of pattern recognition receptors, known to bind DAMPs (Beraud et al

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doi:10.1186/1741-7015-11-205, PMID: 24229326 Morris G, Maes M (2014) Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways

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While anyone who has had chickenpox in the past can develop shingles later in life, the risk increases with age and weakened immunity