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10.1007/s00018-014-1764-3 Cell

Triple Receptor Binding Profile Glucose-Dependent Insulinotropic Polypeptide Agonism : The structural core of the molecule heavily favors GIP receptor affinity

Your missing organ plays no role in drug processing

A year later Bloom's group published a study which demonstrated that rats completely lost interest in food when GLP- 1 (7-36) was injected directly into the hypothalamus part of their brains

Reviews and overviews consistently describe it as a multi-receptor peptide being studied for obesity and metabolic control, with a receptor profile broader than earlier incretin agents

We don't fully understand the weight loss-independent mechanisms through which GLP-1 reduces inflammation is it through the brain, or via T cells, or other pathways