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The added impact of GLP-1s The rapidly changing GLP-1 landscape is only compounding this challenge

In light of the observed mRNA levels of steroidogenic pathway genes, increases in the number and mean size of HSD17B(+) LCs in rhGH rat testes on PNDs 24 and 31, and the number and mean size of HSD3B(+) LCs in 2 IU/kg rhGH was higher than 1 IU/kg rhGH rat testes, prepubertal rhGH administration might have accelerated the functional differentiation of PLCs into immature, testosterone-producing LCs