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A balanced approach also helps with side effects: a nutrient-focused diet can reduce unwanted symptoms by up to 30%, according to Healthline

Glucose-dependent insulinotropic polypeptide (GIP) inhibits bone resorption independently of insulin and glycemia

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In Phase 3 TRIUMPH-4, retatrutide at 12 mg produced 28.7% body weight loss at 68 weeks vs 2.1% for placebo