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Phase-II Drug Metabolism Most of the time gives metabolite that is: More polar Non-toxic Pharmacologically inactive X = O, N, S Phenol, alcohol and carboxylic acid Amine (aliphatic and aromatic) Thiol Sometimes: Phase-II gives: Less polar conjugate: Methylated drug Acetylated drug Toxic metabolite: Some sulfate conjugates Some Acetylated metabolites
50 & Target In Vitro In Vivo TD value of 3.7 mg/kg and an 50 LD of 4.6 mg/kg 50 [4] in mice
That inconsistency compounds over weeks, making protocol adjustments impossible
To stack safely requires medical oversight
A final FDA decision and any required rulemaking are still awaited
If you want to learn about how food fits and how to make adjustments to keep your blood glucose in range, check out my program On the Plate
